ACADEMIC BACKGROUND

1. Name Surname

 : Tuğçe DEMİREL YALÇINER

2. Date of Birth

 : 23.04.1992

3. Title

 : Dr. Öğr. Üyesi

Contact Information

: tugce.demirelyalciner@uskudar.edu.tr

4. Educational Background

Degree Department University Year
BSc Moleküler Biyoloji ve Genetik İstanbul Kültür Üniversitesi 2015
MSc Tıbbi Biyokimya Marmara Üniversitesi 2017
PhD Tıbbi Biyokimya Marmara Üniversitesi 2023

5. Academic Titles

Degree Department University Year
Assistant Professor Tıbbi Biyokimya Üsküdar Üniversitesi 2023

6. Supervised Theses

7. Publications

7.1. Papers published in internationally refereed journals (Scopus Indexed)

  1. Isot I., Kim S. H., Demirel-Yalciner T., Migni A., Gioiello A., Galli F., Sozen E., Surh Y., Ozer N. K., Garcinoic acid enhances inflammation resolution against colitis by activating Nrf2 dependent efferocytosis, Free Radical Biology and Medicine, (2025), 237(), 37-45, .
  2. Mese-Tayfur S., Demirel-Yalcıner T., Migni A., Bartolini D., Galli F., Ozer N. K., Sozen E., Modulation of inflammatory signaling by vitamin E metabolites and its therapeutic implications, Free Radical Research, (2025), (), , .
  3. Sahin A., Demirel-Yalciner T., Sozen E., Ozer N. K., Protective effect of alpha-tocopherol on lipogenesis and oxysterol production in hypercholesterolemia-induced nonalcoholic steatohepatitis, Redox Biology, (2024), (), , .
  4. Demirel-Yalciner T., Cetinkaya B., Sozen E., Ozer N. K., Impact of Seipin in cholesterol mediated lipid droplet maturation; status of endoplasmic reticulum stress and lipophagy, Mechanisms of Ageing and Development, (2024), 219(), 111933, .
  5. Sozen E., Demirel-Yalciner T., Sari D., Ozer N. K., Cholesterol accumulation in hepatocytes mediates IRE1/p38 branch of endoplasmic reticulum stress to promote nonalcoholic steatohepatitis, Free Radical Biology and Medicine, (2022), 191(), 1-7, .
  6. Demirel-Yalciner T., Sozen E., Ozer N. K., Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases, Frontiers in Aging, (2022), 2(), 702-790, .
  7. ERDİ S. A., TUĞÇE D., Kutay K., MERVE A. E., FERİHA E., NESRİN K. Ö., High cholesterol diet activates ER stress mediated apoptosis in testes tissue: Role of α-tocopherol, IUBMB LIFE, (2021), (), 85-92, .
  8. Demirel‐Yalciner T., Sozen E., Ozaltin E., Sahin A., Ozer N. K., alpha‐Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis, BioFactors, (2020), (), 403-413, .
  9. ERDİ S. A., BURAK Y., ENİS T. O., tugçe d., FERİHA E., Jonathan P., NESRİN K. Ö., Cholesterol induced autophagy via IRE1/JNK pathway promotes autophagic cell death in heart tissue, Metabolism, (2020), 106(), 1 - 12, .
  10. Sozen E., Demirel T., Ozer N. K., Vitamin E: Regulatory role in the cardiovascular system, IUBMB Life, (2019), (), 507-515, .

7.2. Papers published in other internationally peer-reviewed journals

  1. Sozen E., Demirel-Yalciner T., Sari D., Avcilar C., Samanci T. F., Ozer N. K., Deficiency of SREBP1c modulates autophagy mediated lipid droplet catabolism during oleic acid induced steatosis, Metabolism Open, (2021), 12(), 100138, .
  2. SOZEN E., DEMIREL-YALCINER T., DEMIR D. D., OZNACAR B., OZER N. K., SREBP1c silencing reduces endoplasmic reticulum stress and related apoptosis in oleic acid induced lipid accumulation, Marmara Medical Journal, (2021), 34(3), 241 - 247, .

7.3. Assertions presented in international scientific congresses and published in the proceedings

  1. Demirel-Yalciner T., Cetinkaya B., Sozen E., Ozer. N. K., Hepatocyte seipin silencing reduces cholesterol mediated lipid droplet maturation in fatty liver model., Redox Biology: A Paradigm of the Foundation of Life, Serbian Society for Mitocondrial and Free Radical Physiology, (27.09.2024), Belgrad
  2. Demirel-Yalciner u., Cetinkaya B., Sozen E., Ozer N. K., HEPATIC SEIPIN DEFICIENCY REDUCES CHOLESTEROL MEDIATED LIPID DROPLET MATURATION DEPENDENT OF ENDOPLASMIC RETICULUM STRESS BUT NOT LIPOPHAGY., Annual Meeting of SFRR-E 2024 From Molecules to Tissues: Redox Biology in Action, (05.06.2024), İstabul-Türkiye
  3. B C., T D., E S., Ozer NK., Garcinoic Acid Alleviates Cholesterol Mediated Lipid Accumulation in Hepatocytes: Role of NRF2/HO-1 Pathway., SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, (05.06.2024), İstanbul-Türkiye
  4. S M., T D., NK O., Sozen E., Role Of SREBP1c And Lipophagy In Fructose Mediated Lipid Accumulation In Hepatocytes., SFRR-E Annual Meeting 2024 “From Molecules To Tissues: Redox Biology In Action, (04.06.2024), İstanbul-Türkiye

7.4. International books or chapters

7.5. Papers published in national peer-reviewed journals

7.6. Assertions presented in national scientific congresses and published in the proceedings

7.7. Other publications

Books published by national publishers

Book chapters published by national publishers

8. Projects

  1. Sözen D. D. E., YALÇINER T. D., ÖZER N. K., Elmas D. D. M. A., Özer D. S., TÜBİTAK, Uzun zincirli vitamin E metaboliti garsinoik asit etkinliğinin farelerde oluşturulacak yağlı karaciğer modelinde değerlendirilmesi, (Researcher), (Expire date :08.08.2028),
  2. Sözen D. A. E., YALÇINER T. D., ÖZER N. K., Elmas D. D. M. A., Özer D. S., TÜBİTAK, : Uzun zincirli vitamin E metaboliti garsinoik asit etkinliğinin farelerde oluşturulacak yağlı karaciğer modelinde değerlendirilmesi, (Researcher), (Expire date :08.08.2028),
  3. SOZEN E., YALÇINER T. D., ÖZER S., ÖZER N. K., TÜBİTAK, Alfa-13-COOH yüklü makrofaj hedefli nanopartikül etkinliğinin yağlı karaciğer hastalığında incelenmesi, (Researcher), (Expire date :16.07.2027),
  4. SOZEN E., YALÇINER T. D., ÖZER S., ÖZER N. K., TÜBİTAK, Alfa-13-COOH Yüklü Makrofaj Hedefli Nanopartikül Etkinliğinin Yağlı Karaciğer Hastalığında Incelenmesi”, (Researcher), (Expire date :16.07.2027),
  5. Sözen E., YALÇINER T. D., ÖZER N. K., TÜBİTAK, SREBP1c inhibisyonunun fruktoz ile indüklenen lipit birikimine etkisinin hepatositlerde belirlenmesi, (Researcher), (Expire date :01.03.2025),
  6. Sözen E., YALÇINER T. D., ÖZER N. K., TÜBİTAK, SREBP1c İinhibisyonunun fruktoz ile indüklenen lipit birikimine etkisinin hepatositlerde belirlenmesi, (Researcher), (Expire date :01.03.2025),
  7. ÖZER N. K., YALÇINER T. D., TÜBİTAK, Kolesterol ile indüklenen in vitro lipit birikimi ve in vivo NASH modellerinde NRF-2 aktivasyonunun etkisi, (Researcher), (Expire date :13.12.2026),
  8. ÖZER N. K., YALÇINER T. D., Sözen E., Elmas M. A., , Kolesterol ile İndüklenen İn vitro lipit birikimi ve in vivo NASH modellerinde Nrf-2 aktivasyonunun etkisi, (Researcher), (Expire date :13.12.2026),
  9. ÖZER N. K., YALÇINER T. D., Sözen E., İnce Ü., Elmas M. A., Özcan L., TÜBİTAK, Seipin Proteinin Yüksek Kolesterollü Diyet ile Indüklenen Yağlı Karaciğer Hastalığındaki Rolünün Saptanması, (Researcher), (Expire date :15.06.2024),
  10. ÖZER N. K., YALÇINER T. D., SÖZEN E., İNCE Ü., TÜBİTAK, Seipin Proteinin Yüksek Kolesterollü Diyet ile İndüklenen Yağlı Karaciğer Hastalığındaki Rolünün Saptanması, (Researcher), (Expire date :15.06.2024),

9. Administrative Duties

  1. Merkez Müdür Yardımcısı / Deputy Head of Research Center - METİFLAM Müdür Yardımcısı (2024-Continues)
  2. Koordinatör / Coordinator - Ders Yılı Koordinatörü - Tıp Fakültesi (2025-Continues)
  3. Kurul Üyeliği / Board Member - ARGEYEP Yürütme Kurulu Üyeliği (2024-Continues)
  4. Çalışma Grubu Üyelikleri / Research Group Membership - Nörogenetik Çalışma Grubu (2024-Continues)

10. Scientific Memberships

11. Awards

12. Coourses recently given

Academic Year Semester Course name Hours Number of Students
Theoretical Application
2024-2025 Spring Medical Committee Courses (Committee 3B) (Undergraduate) - Group 1 18 8 93
Medical Committee Courses (Com 2B) (Undergraduate) - Group 1 17 0 80
Volunteering Work (Undergraduate) - Group 1 1 2 42
Medical Committee Courses (Committee 1B) (Undergraduate) - Group 1 7 0 71
Committee of Basic Sciences in Dentistry II (Undergraduate) - Group 1 8 6 11
Fall Genel Beslenme ve Biyokimya (Undergraduate) - Group 1 2 0 81
Medical Committee Courses (Com 1A) (Undergraduate) - Group 1 7 0 62
Medical Committee Courses (Com 2A) (Undergraduate) - Group 2 15 0 238
Medical Committee Courses (Committee 3A) (Undergraduate) - Group 1 16 6 94
Committee of Basic Sciences in Dentistry I (Undergraduate) - Group 1 4 0 11

Created: 18.09.2025